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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cai, Hongxia Mu, Zhihao Jiang, Zhen Wang, Yongting Yang, Guo Yuan Zhang, Zhijun |
| Copyright Year | 2015 |
| Abstract | Matrix metalloproteinase-9 (MMP-9) plays a beneficial role in the sub-acute phase after ischemic stroke. However, unrestrained MMP-9 may disrupt the blood-brain barrier (BBB), which has limited its use for the treatment of brain ischemia. In the present study, we constructed lentivirus mediated hypoxia-controlled MMP-9 expression and explored its role after stroke. Hypoxia response element (HRE) was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion. Lentiviruses were injected into the peri-infarct area on day 7 after transient ischemia. We found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia, and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV group. Furthermore, mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline, GFP, and SB-3CT groups. Therefore, hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke. |
| Starting Page | 550 |
| Ending Page | 560 |
| Page Count | 11 |
| File Format | |
| ISSN | 16737067 |
| Journal | Neuroscience Bulletin |
| Volume Number | 31 |
| Issue Number | 5 |
| e-ISSN | 19958218 |
| Language | English |
| Publisher | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
| Publisher Date | 2015-05-15 |
| Publisher Place | Shanghai |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | blood-brain barrier hypoxia response element matrix metalloproteinase 9 stroke Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Physiology Medicine |
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