NDLI: Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration

Content Provider	Springer Nature Link
Author	Mu, Zhaoxia Zhang, Shuqiang He, Chunjiao Hou, Haitao Liu, Dong Hu, Nan Xu, Hui
Copyright Year	2016
Abstract	The SoxC transcription factors (Sox4, Sox11, and Sox12) play important roles in the development of the vertebrate eye and retina. However, their expression and function during retinal and optic nerve regeneration remain elusive. In this study, we investigated the expression and possible functions of the SoxC genes after retinal and optic nerve injury in adult zebrafish. We found that among the five SoxC members, Sox11b was strongly induced in BrdU-positive cells in the inner nuclear layer (INL) after retinal injury, and morpholino-mediated Sox11b-knockdown significantly reduced the number of proliferating cells in the INL at 4 days post-injury. After optic nerve lesion, both Sox11a and Sox11b were strongly expressed in retinal ganglion cells (RGCs), and knockdown of both Sox11a and Sox11b inhibited RGC axon regrowth in retinal explants. Our study thus uncovered a novel expression pattern of SoxC family genes after retinal and optic nerve injury, and suggests that they have important functions during retinal and optic nerve regeneration.
Starting Page	53
Ending Page	61
Page Count	9
File Format	PDF
ISSN	16737067
Journal	Neuroscience Bulletin
Volume Number	33
Issue Number	1
e-ISSN	19958218
Language	English
Publisher	Springer Singapore
Publisher Date	2016-10-14
Publisher Place	Singapore
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	SoxC Sox11 Expression Zebrafish Retina Optic nerve Regeneration Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology Medicine

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