NDLI: Activation of Parvalbumin-Positive Neurons in Both Retina and Primary Visual Cortex Improves the Feature-Selectivity of Primary Visual Cortex Neurons

Content Provider	Springer Nature Link
Author	Duan, Jinggang Fu, Hang Zhang, Jiayi
Copyright Year	2017
Abstract	Several recent studies using either viral or transgenic mouse models have shown different results on whether the activation of parvalbumin-positive (PV$^{+}$) neurons expressing channelrhodopsin-2 (ChR2) in the primary visual cortex (V1) improves the orientation- and direction-selectivity of V1 neurons. Although this discrepancy was thoroughly discussed in a follow-up communication, the issue of using different models to express ChR2 in V1 was not mentioned. We found that ChR2 was expressed in retinal ganglion cells (RGCs) and V1 neurons in ChR2$^{fl/+}$; PV-Cre mice. Our results showed that the activation of PV$^{+}$ RGCs using white drifting gratings alone significantly decreased the firing rates of V1 neurons and improved their direction- and orientation-selectivity. Long-duration activation of PV$^{+}$ interneurons in V1 further enhanced the feature-selectivity of V1 neurons in anesthetized mice, confirming the conclusions from previous findings. These results suggest that the activation of both PV$^{+}$ RGCs and V1 neurons improves feature-selectivity in mice.
Starting Page	255
Ending Page	263
Page Count	9
File Format	PDF
ISSN	16737067
Journal	Neuroscience Bulletin
Volume Number	33
Issue Number	3
e-ISSN	19958218
Language	English
Publisher	Springer Singapore
Publisher Date	2017-01-10
Publisher Place	Singapore
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Parvalbumin neurons visual cortex Retinal ganglion cells Optogenetics Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology Medicine

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