NDLI: Protective effects of Cornus walteri W. extracts on t-BHP-induced cell damage through antioxidant activity

Content Provider	Springer Nature Link
Author	Kim, Yon Suk Hwang, Jin Woo Kang, Seo Hee Kim, Hye Ran Je, Jae Young Kim, Ee Hwa Jeon, You Jin Moon, Sang Ho Jeon, Byong Tae Park, Pyo Jam
Copyright Year	2013
Abstract	This study evaluated the antioxidant potential of extracts from Cornus walteri W. (CW) using various assays for natural antioxidants. We determined the polyphenol and flavonoid contents, as well as the antioxidant properties of water and ethanol extracts from the CW compared with those of other natural and synthetic antioxidants. CW extracts had high total phenolic and flavonoid contents in both the water and ethanol extracts. Various radical (DPPH, hydroxyl, and alkyl) scavenging activities of extracts from CW were higher than that of vitamin C. In addition, the antioxidant capacity measured as ferric reducing antioxidant power (FRAP), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) as diammonium salt (ABTS) radical scavenging were higher than that of 2,6-di-tert-butyl-4-methylphenol (BHT), used as a positive control. The cytoprotective effect of CW extracts was also observed in tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in Chang cells. These results showed that CW extracts have antioxidant properties through their ability to enhance cell viability, prevent reactive oxygen species (ROS) generation, and inhibit mitochondrial membrane depolarization. The antioxidant potency of the CW extracts could be exploited for their health promoting potential.
Starting Page	819
Ending Page	826
Page Count	8
File Format	PDF
ISSN	12268372
Journal	Biotechnology and Bioprocess Engineering
Volume Number	18
Issue Number	4
e-ISSN	19763816
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-08-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cornus walteri W. antioxidant activity free radical t-BHP chang cell oxidative stress Biotechnology Industrial and Production Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Applied Microbiology and Biotechnology Biotechnology

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