NDLI: Polymer based cardiovascular gene therapy

Content Provider	Springer Nature Link
Author	Choi, Donghoon
Copyright Year	2007
Abstract	Therapeutic angiogenesis is a new potential treatment in cardiovascular disease. It is performed by the delivery of the angiogenic agents (protein, gene). Most important consideration for gene therapy is the construction of an effective therapeutic gene. Currently, VEGF is the most effective therapeutic gene for the neovascularization. We constructed the hypoxia-regulated VEGF plasmid using the Epo enhancer and RTP801 promoter. The efficiency of the pEpo-SV-VEGF and pRTP801-VEGF were evaluated by various methodsin vitro andin vivo. The results suggested that the hypoxia-inducible VEGF gene therapy system is effective and safe, which may be useful for the gene therapy of ischemic heart disease. Development of a safe and efficient gene carrier is another main requirement for successful gene therapy. Although viralbased gene delivery is currently the most effective way to transfer genes to cells, nonviral vectors are increasingly being considered forin vivo gene delivery. The advantages of nonviral gene therapy are lack of specific immunogenecity, simplicity of use, and ease of large-scale production. In addition, the simple conjugation of a targeting moiety to nonviral gene carrier can facilitate tissue-targeting gene delivery. We have developed two new gene carrier systems, TerplexDNA and WSLP (water soluble lipopolymer). These two are efficient carrier to ischemic myocardium and has low toxicity and high transfection efficiency. So it may allow for application ofin vivo gene therapy in the treatment of heart disease.
Starting Page	39
Ending Page	42
Page Count	4
File Format	PDF
ISSN	12268372
Journal	Biotechnology and Bioprocess Engineering
Volume Number	12
Issue Number	1
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	angiogenesis VEGF polymer Biotechnology Industrial and Production Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Applied Microbiology and Biotechnology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Psoraleae semen extract inhibits angiogenesis and adipogenesis

Production and on-column re-folding of human vascular endothelial growth factor 165 in Escherichia coli

Tissue engineered scaffold utilizing the reinforced technique

Notice of withdrawal

LDL coating pVEGF/polyethylenimine complex enhances vascular endothelial growth factor expression

Biodegradable molecularly imprinted polymers based on poly(ε-caprolactone)

Anti-angiogenesis and anti-adipogenesis effects of Anthrisci radix extract

Inhibitory effects of Siegesbeckiae herba extract on angiogenesis and adipogenesis

Bioinspired polymers that control intracellular drug delivery

Polymer based cardiovascular gene therapy

Similar Documents

Psoraleae semen extract inhibits angiogenesis and adipogenesis

Production and on-column re-folding of human vascular endothelial growth factor 165 in Escherichia coli

Tissue engineered scaffold utilizing the reinforced technique

Notice of withdrawal

LDL coating pVEGF/polyethylenimine complex enhances vascular endothelial growth factor expression

Biodegradable molecularly imprinted polymers based on poly(ε-caprolactone)

Anti-angiogenesis and anti-adipogenesis effects of Anthrisci radix extract

Inhibitory effects of Siegesbeckiae herba extract on angiogenesis and adipogenesis

Bioinspired polymers that control intracellular drug delivery

Polymer based cardiovascular gene therapy