NDLI: Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas

Content Provider	Springer Nature Link
Author	Arslantas, Ali Artan, Sevilhan Öner, Ülkü Müslümaglu, M. Hamza Özdemir, Muhsin Durmaz, Ramazan Arslantas, Didem Vural, Murat Cosan, Erhan Atasoy, Metin Ant
Copyright Year	2007
Abstract	To extend our understanding of potential stepwise genetic alterations that may underlie tumor progression from low-grade astrocytomas to glioblastomas, histopathologic and comparative genomic hybridization analyses were performed on tumor specimens from 68 primary lesions, including 40 glioblastomas, 10 anaplastic and 18 low-grade astrocytomas. The number of aberrations per case increased towards the higher grade tumors (grade II: 1.66±1.49; grade III: 2.80±1.68; grade IV: 3.02±1.07; F=6.955, p=0.002). A gain of 7/7q was common and the most frequently seen aberration in low-grade astrocytomas, whereas loss of 10q was the most frequently seen anomaly in anaplastic astrocytomas and glioblastomas. Chromosome 7p amplification was only detected in glioblastomas. Chromosome 10/10q deletion and combination of lp, 19q and 17p deletions were specific to high-grade astrocytic tumors. Sequences of chromosome 7 and 10 seem to have pivotal roles in the biology of human gliomas. The genomic copy deletions of chromosomes lp and 19q might provide an alternative mechanism in the genesis of astrocytomas.
Starting Page	39
Ending Page	46
Page Count	8
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	13
Issue Number	1
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2007-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	anaplastic astrocytoma comparative genomic hybridization genomic imbalances glioblastoma multiforme low-grade astrocytoma Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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