NDLI: Poorly differentiated synovial sarcoma: A case report

Content Provider	Springer Nature Link
Author	Cappello, Francesco Bellafiore, M. Bucchieri, F. Balsa, G. Palma, A. Zummo, G.
Copyright Year	2001
Abstract	Poorly differentiated synovial sarcoma is a rare soft tissue tumor. We studied a case arising in the pleural cavity of a young subject, characterised by the presence of spindle cell, small cell, and large epithelioid cell areas. We performed stains for mucosubstances and analysed the expression of cytokeratins 5/6, 7, 8, 18, 19, CEA, CD34, Ber-Ep4 and calretinin to characterize the phenotype of this neoplasm. We furthermore assessed immunohistochemically the presence of p53, Bcl-2, Bax and caspase 3, four apoptotic markers, to evaluate a relationship between apoptotic activity and the behaviour of this tumor. Our findings showed a strong presence of calretinin, p53 and Bcl-2 in all three areas. The possibility that poorly differentiated synovial sarcoma could be calretininpositive was a new data, to our knowledge, and it could be of some importance in diagnostic pathology. Moreover, the negligible positivity for Bax and caspase 3 suggested that the minor role of programmed cell death could be one of the causes of the aggressive behaviour of this tumor. These data also suggest that the reduction of apoptotic phenomena in poorly differentiated synovial sarcoma could be considered one of the major mechanisms of tumoral growth.
Starting Page	63
Ending Page	66
Page Count	4
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	7
Issue Number	1
Language	English
Publisher	Springer Netherlands
Publisher Date	2001-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	synovial sarcoma poorly differentiated synovial sarcoma soft tissue tumors calretinin apoptosis Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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