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| Content Provider | Springer Nature Link |
|---|---|
| Author | Szomor, Árpád Saati, Talal Al Delsol, Georges Kereskai, László Szijártó, Zsuzsanna Losonczy, Hajna |
| Copyright Year | 2007 |
| Abstract | We present a case of a 60-year-old male patient with primary bone marrow anaplastic large cell lymphoma. He was admitted to the hospital with the symptoms of anemia and fever. There was no evidence of lymphadenopathy or splenomegaly. Immunoelectrophoresis showed the presence of a triple M gradient (double IgM and an IgG), with the IgG and one of the IgM paraproteins functioning as a cryoglobulin. The patient had no hepatitis C virus infection. Bone marrow biopsy showed massive CD30-positive, ALK-negative large lymphoid cell infiltration of T-cell origin with anaplastic morphology. PCR analysis of lymphoid cells separated from the bone marrow demonstrated the presence of a B/T hybrid genotype disorder with no evidence of the t(2;5), nor t(1;2) translocations. The patient entered a period of remission following CHOP chemotherapy. The patient subsequently died of sepsis as a consequence of serious humoral immunodeficiency. |
| Starting Page | 260 |
| Ending Page | 262 |
| Page Count | 3 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 13 |
| Issue Number | 3 |
| e-ISSN | 15322807 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2007-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | anaplastic large cell lymphoma T-cell receptor gene rearrangement immunoglobulin heavy chain gene rearrangement M gradient bone marrow Cancer Research Oncology Pathology Immunology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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