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| Content Provider | Springer Nature Link |
|---|---|
| Author | Dehaghani, Alamtaj Samsami Rad, Neda Rahimi Fattahi, Mohammad Javad Khadang, Baharak Kashef, Mohammad Amin Sarraf, Zahra Ghaderi, Abbas |
| Copyright Year | 2008 |
| Abstract | HER2/neu and TGF-β1 are over-expressed in various types of malignancies. It appears that they play an important role in the biologic behavior of tumors and have prognostic value. Gestational tropoblastic diseases (GTDs) comprise of a heterogeneous group characterized by abnormally proliferating trophoblastic tissues, ranging from benign to malignant. The objective of this study was to measure and compare the serum levels of s-HER2 and TGF-β between patients with GTDs and pregnant and non-pregnant controls. Serum levels of s-HER2 and TGF-β1 were determined by ELISA method in 95 GTD patients (55 complete moles, 32 persistent moles, and 8 choriocarcinoma), 30 normal pregnant controls, and 22 normal non-pregnant controls. Mean serum level of s-HER2 did not differ significantly between patients and controls. TGF-β1 serum level was significantly higher in GTD patients (20.29 ± 10.68 pg/ml with 95% confidence interval (CI) of 18.10–22.48 pg/ml) compared with pregnant controls (10.26 ± 11.84 pg/ml with 95% CI of 5.75–14.76 pg/ml) and non-pregnant controls (7.27 ± 9.61 pg/ml with 95% CI of 3.01–11.53 pg/ml) (P < 0.001). Our findings suggest that TGF-β1 serum levels in GTD patients may represent a potential prognostic marker. Further investigations with larger sample size and more frequent sampling are required to elucidate this issue. |
| Starting Page | 37 |
| Ending Page | 40 |
| Page Count | 4 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 15 |
| Issue Number | 1 |
| e-ISSN | 15322807 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2008-10-31 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | HER2 TGF-β1 Gestational trophoblastic disease Biomedicine general Immunology Pathology Oncology Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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