NDLI: A solitary cutaneous tumor with distinct areas of verruca and seborrheic keratosis-like lesion

Content Provider	Springer Nature Link
Author	Ch Lazaris, Andreas Paraskevakou, Helen S Davaris, Panayiotis
Copyright Year	1999
Abstract	A single, exophytic, cutaneous tumor on the thigh of a 52-year-old man was examined by light microscopy, in situ hybridization and immunohis-tochemistry. It demonstrated distinct areas of verruca and of seborrheic keratosis-like morphology simultaneously. Focally, architectural abnormalities were noted in some deeper parts of the tumor, but there was no morphological evidence of malignancy. The patient has remained disease-free for two and a half years after surgery. Biotinylated full genomic DNA probes of HPV confirmed the presence of types 6/11 exclusively in the verrucous portion of the neoplasm. In the verrucous component p53 protein was overexpressed and, additionally, increased Ki-67 immunopositive signals were detected, being localized below the HPV-DNA-expressing spinous cells.
Starting Page	320
Ending Page	323
Page Count	4
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	5
Issue Number	4
Language	English
Publisher	Springer Netherlands
Publisher Date	1999-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	HPV seborrheic keratosis skin in situ hybridization Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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A solitary cutaneous tumor with distinct areas of verruca and seborrheic keratosis-like lesion