NDLI: Low Frequency of PIK3CA Gene Mutations in Hepatocellular Carcinoma in Chinese Population

Content Provider	Springer Nature Link
Author	Li, Xun Zhang, Quanbao He, Wenting Meng, Wenbo Yan, Jun Zhang, Lei Zhu, Xiaoliang Liu, Tao Li, Yumin Bai, Zhongtian
Copyright Year	2011
Abstract	PI3K/AKT constitutes an important pathway regulating the signaling of multiple biological processes and plays a critical role in carcinogenesis. PIK3CA gene missense mutations have been reported in many human cancer types. The mutation of it in hepatocellular carcinoma cases varies with different races and regions. In this study, we investigated PIK3CA mutation in Chinese hepatocellular carcinoma patients. A total 90 Chinese patients of hepatocellular carcinoma were recruited in this study. Exons 9 and 20 hotspots mutations of PIK3CA gene were detected by PCR-based DNA sequencing. Two point mutations (E542K and D549H) in exon 9 were found in only one patient (1/90; 1.11%), no mutation was found in exon 20 in any cases. 57 patients are associated with HBV infection (57/90; 63.3%), and 8 patients with HCV infection (8/90; 8.9%). The frequency of the PIK3CA mutations in hepatocellular carcinoma seems to be lower in Chinese hepatocellular carcinoma patients. These findings suggest that PI3K mutations may not play a major role in hepatic carcinogenesis in Chinese. HBV infection has close relationship with HCC in Chinese.
Starting Page	57
Ending Page	60
Page Count	4
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	18
Issue Number	1
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-06-12
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Hepatocellular carcinoma PIK3CA Gene mutation Hepatitis B virus Immunology Biomedicine general Pathology Oncology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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