NDLI: Reduced β-catenin Expression is Associated with Good Prognosis in Astrocytoma

Content Provider	Springer Nature Link
Author	Zhang, Li Ying Jiang, Li Na Li, Fan Fan Li, Hang Liu, Fang Gu, Yu Song, Yue Zhang, Feng Ye, Jing Li, Qing
Copyright Year	2009
Abstract	The aim of this study was to evaluate the expression of β-catenin in astrocytoma, and the clinical relevance and prognostic significance of the expression of β-catenin was also analyzed. Immunohistochemistry was performed on 63 resected astrocytoma tumor specimens to detect the expression of β-catenin. The correlation between the results of immuoexpression and the clinicopathologic parameters and patient survival was processed statistically. In 63 samples of astrocytoma, 36 cases were immunoreactive for β-catenin at cytoplasm, ten cases of astrocytoma were immunoreactive at cytomembrane, and four cases of astrocytoma were stained for β-catenin at nucleus. Spearman analysis showed that the distribution of β-catenin was not correlated with the grades of astrocytoma. However, the expression profiles were correlated with the patient’s 2-year survival, but not correlated with the grades, tumor size, sex, age, or tumor location. Patients with low β-catenin expression levels tended to be associated with a better prognosis than those who with high levels (p = 0.042). Our results suggest that β-catenin is useful for the prognosis evaluation of astrocytoma.
Starting Page	253
Ending Page	257
Page Count	5
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	16
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-12-11
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Astrocytoma β-catenin Prognosis Immunohistochemistry Biomedicine general Immunology Pathology Oncology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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