NDLI: Association and Prognostic Significance of the Functional −1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer

Content Provider	Springer Nature Link
Author	Avcı, Nilufer Ture, Mehmet Deligonul, Adem Cubukcu, Erdem Olmez, Omer Fatih Sahinturk, Serdar Topak, Ali Kurt, Ender Evrensel, Turkkan Şahin, Ahmet Bilgehan Yakut, Tahsin
Copyright Year	2015
Abstract	Matrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case–control design the association between the functional −1562C/T polymorphism in the promoter region of MMP-9 and gastric cancer (GC) in a Turkish sample. Second, we examined its prognostic significance in GC patients. A total of 144 subjects were enrolled in the case–control study (79 GC cases and 65 controls). Overall survival (OS) and progression-free survival (PFS) served as the main outcome measures in the longitudinal study. The MMP-9 −1562C/T polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. The odds ratio (OR) of GC for the CC genotype relative to the CT+TT genotypes was not significant (OR = 0.89, 95 % confidence interval [CI] = 0.44–1.82, P = 0.75). These results did not change after allowance for age and sex in multivariable regression analysis (OR = 0.81, 95 % CI = 0.40–1.94, P = 0.84). When the MMP-9 −1562C/T polymorphism was analyzed among GC patients in relation to OS and PFS, we found no significant differences between subjects with the CC and CT+TT genotypes. In conclusion, the results of our study did not point toward a major role of the MMP-9 −1562C/T polymorphism in the pathogenesis and clinical course of GC in Turkish subjects.
Starting Page	1243
Ending Page	1247
Page Count	5
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	21
Issue Number	4
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-07-09
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Gastric cancer Matrix metalloproteinases Polymorphism Association study Prognosis Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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