NDLI: Conserved termini and adjacent variable region of Twortlikevirus Staphylococcus phages

Content Provider	Springer Nature Link
Author	Zhang, Xianglilan Kang, Huaixing Li, Yuyuan Liu, Xiaodong Yang, Yu Li, Shasha Pei, Guangqian Sun, Qiang Shu, Peng Mi, Zhiqiang Huang, Yong Zhang, Zhiyi Liu, Yannan An, Xiaoping Xu, Xiaolu Tong, Yigang
Copyright Year	2015
Abstract	Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of serious infection, both in the community and hospital settings. Despite sophisticated strategies and efforts, the antibiotic options for treating MRSA infection are narrowing because of the limited number of newly developed antimicrobials. Here, four newly-isolated MRSA-virulent phages, IME-SA1, IMESA2, IME-SA118 and IME-SA119, were sequenced and analyzed. Their genome termini were identified using our previously proposed "termini analysis theory". We provide evidence that remarkable conserved terminus sequences are found in IME-SA1/2/118/119, and, moreover, are widespread throughout Twortlikevirus Staphylococcus phage G1 and K species. Results also suggested that each phage of the two species has conserved 5′ terminus while the 3′ terminus is variable. More importantly, a variable region with a specific pattern was found to be present near the conserved terminus of Twortlikevirus S. phage G1 species. The clone with the longest variable region had variable terminus lengths in successive generations, while the clones with the shortest variable region and with the average length variable region maintained the same terminal length as themselves during successive generations. IME-SA1 bacterial infection experiments showed that the variation is not derived from adaptation of the phage to different host strains. This is the first study of the conserved terminus and variable region of Twortlikevirus S. phages.
Starting Page	433
Ending Page	440
Page Count	8
File Format	PDF
ISSN	16740769
Journal	Virologica Sinica
Volume Number	30
Issue Number	6
e-ISSN	1995820X
Language	English
Publisher	Wuhan Institute of Virology, CAS
Publisher Date	2015-12-14
Publisher Place	Wuhan
Access Restriction	Subscribed
Subject Keyword	Twortlikevirus Staphylococcus phage conserved termini variable region Virology Medical Microbiology Oncology Biochemistry Microbiology Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology Molecular Medicine

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