NDLI: Immunogenicity and protective efficacy of recombinant M2e.Hsp70c (Hsp70$_{359–610}$) fusion protein against influenza virus infection in mice

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Immunogenicity and protective efficacy of recombinant M2e.Hsp70c (Hsp70$_{359–610}$) fusion protein against influenza virus infection in mice

Content Provider	Springer Nature Link
Author	Attaran, Hamidreza Nili, Hassan Tebianian, Majid
Copyright Year	2014
Abstract	New strategies in vaccine development are urgently needed to combat emerging influenza viruses and to reduce the risk of pandemic disease surfacing. Being conserved, the M2e protein, is a potential candidate for universal vaccine development against influenza A viruses. Mycobacterium tuberculosis Hsp70 (mHsp70) is known to cultivate the function of immunogenic antigenpresenting cells, stimulate a strong cytotoxic T lymphocyte (CTL) response, and stop the induction of tolerance. Thus, in this study, a recombinant protein from the extracellular domain of influenza A virus matrix protein 2 (M2e), was fused to the C-terminus of Mycobacterium tuberculosis Hsp70 (Hsp70c), to generate a vaccine candidate. Humoral immune responses, IFN-γ-producing lymphocyte, and strong CTL activity were all induced to confirm the immunogenicity of M2e.Hsp70c (Hsp70$_{359–610}$). And challenge tests showed protection against H1N1 and H9N2 strains in vaccinated groups. Finally these results demonstrates M2e.Hsp70c fusion protein can be a candidate for a universal influenza A vaccine.
Starting Page	218
Ending Page	227
Page Count	10
File Format	PDF
ISSN	16740769
Journal	Virologica Sinica
Volume Number	29
Issue Number	4
e-ISSN	1995820X
Language	English
Publisher	Wuhan Institute of Virology, CAS
Publisher Date	2014-08-18
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	influenza A virus M2e.Hsp70 recombinant fusion protein universal influenza vaccine Virology Medical Microbiology Oncology Biochemistry Microbiology Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Immunology Molecular Medicine

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