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| Content Provider | Springer Nature Link |
|---|---|
| Author | Guo, Rong Shen, Shu Zhang, Yanfang Shi, Junming Su, Zhengyuan Liu, Dan Liu, Jinliang Yang, Juan Wang, Qiguo Hu, Zhihong Zhang, Yujiang Deng, Fei |
| Copyright Year | 2017 |
| Abstract | Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents. |
| Starting Page | 80 |
| Ending Page | 88 |
| Page Count | 9 |
| File Format | |
| ISSN | 16740769 |
| Journal | Virologica Sinica |
| Volume Number | 32 |
| Issue Number | 1 |
| e-ISSN | 1995820X |
| Language | English |
| Publisher | Springer Singapore |
| Publisher Date | 2017-02-27 |
| Publisher Place | Singapore |
| Access Restriction | Subscribed |
| Subject Keyword | Crimean-Congo hemorrhagic fever virus (CCHFV) newborn mice genotype phylogenetic analysis Virology Medical Microbiology Oncology Biochemistry Microbiology Microbial Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Immunology Molecular Medicine |
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