NDLI: Drug release properties of polyethylene-glycol-treated ciprofloxacin-Indion 234 complexes

Content Provider	Springer Nature Link
Author	Pisal, Sambhaji Zainnuddin, Rana Nalawade, Pradeep Mahadik, Kakasaheb Kadam, Shivajirao
Copyright Year	2004
Abstract	The polyethylene glycol (PEG) treatment of ciprofloxacin-Indion 234 complex was aimed to retard rapid ion exchange drug release at gastric pH. Ciprofloxacin loading on Indion 234 was performed in a batch process, and the amount of K$^{+}$ in Indion 234 displaced by drug with time was studied as equilibrium constant K$_{DM}$. Drug-resin complex (DRC) was treated with aqueous PEG solution (0.5%–2% wt/vol) of different molecular weights (MWs) for 2 to 30 minutes. The PEG-treated ciprofloxacin-Indion 234 complex was evaluated for particle size, water absorption time, and drug release at gastric pH. During drug loading on Indion 234, the equilibrium constant (K$_{DM}$) increased rapidly up to 20 minutes with efficient drug loading. Increased time of immersion of the drug resinate in PEG solutions significantly retained higher size particles upon dehydration. The larger DRC particles showed longer water absorption times owing to compromised hydrating power. The untreated DRC showed insignificant drug release in deionized water; while at gastric pH, ciprofloxacin release was complete in 90 minutes. A trend of increased residual particle size, proportionate increase in water absorption time, and hence the retardation of release with time of immersion was evident in PEG-treated DRC. The time of immersion of DRC in PEG-treated DRC. The time of immersion of DRC in PEG solution had predominant release retardant effect, while the effect of molecular weight of PEG was insignificant. Thus, PEG treatment of DRC successfully retards ciprofloxacin ion exchange release in acidic pH.
Starting Page	101
Ending Page	106
Page Count	6
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	5
Issue Number	4
e-ISSN	15309932
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-01-01
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ciprofloxacin Indion complexes PEG immersion particle size water uptake release Biotechnology Biochemistry Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

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