NDLI: Preparation and In Vitro Evaluation of a New Fentanyl Patch Based on Functional and Non-functional Pressure Sensitive Adhesives

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Preparation and In Vitro Evaluation of a New Fentanyl Patch Based on Functional and Non-functional Pressure Sensitive Adhesives

Content Provider	Springer Nature Link
Author	Taghizadeh, Seyed Mojtaba Soroushnia, Arezou Mohamadnia, Fatemeh
Copyright Year	2009
Abstract	In this study, some single-layer and double-layer transdermal drug delivery systems (TDDSs) with different functional and non-functional acrylic pressure-sensitive adhesives (PSAs) were prepared. For this purpose, fentanyl as a drug was used. The effects of PSAs type, single-layer and double-layer TDDSs on skin permeation and in vitro drug release from devices were evaluated using a hydrodynamically well-characterized Chien permeation system fitted with excised rat abdominal skin. The adhesion properties of devices such as peel strength and tack values were obtained as well. It was found that TDDS with –COOH functional PSA showed the lowest steady-state flux. Double-layer TDDS displayed a constant flux up to 72 h. In double- and single-layer devices after 1 and 3 h, respectively, drug release followed Higuchi’s kinetic model. Formulations with the highest percentage of –COOH functional PSA have displayed the lowest flux. The double-layer TDDSs with non-functional PSA demonstrated the suitable skin permeation rate close to Duragesic® TDDS and suitable adhesion properties.
Starting Page	278
Ending Page	284
Page Count	7
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	11
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2010-02-25
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	adhesion properties fentanyl peel strength pressure-sensitive adhesive skin permeation tack transdermal drug delivery system Pharmacy Biochemistry Biotechnology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

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