NDLI: Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF

Content Provider	Springer Nature Link
Author	Bele, Mrudula H. Derle, Diliprao V.
Copyright Year	2011
Abstract	Polacrilin Potassium NF is a commonly used weak cation exchange resin disintegrant in pharmaceutical tablets. The objective of this research was to evaluate the effects of sorbed moisture on physical characteristics and disintegrant performance of four brands of Polacrilin Potassium NF. The disintegrants were stored in five different relative humidity chambers and their dynamic vapor adsorption–desorption analysis, effect of moisture on their compressibility, compactability, particle size, morphology, water uptake rate, and disintegration ability were studied. Moisture seemed to plasticize the disintegrants, reducing their yield pressures. However, certain optimum amount of moisture was found to be useful in increasing the compactablity of the tablets containing disintegrants. The tablets, however, lost their tensile strengths beyond this optimum moisture content. Moisture caused two brands of the disintegrants to swell; however, two other brands aggregated upon exposure to moisture. Swelling without aggregation increased the water uptake, and in turn the disintegrant performance. However, aggregation probably reduced the porosities of the disintegrants, reducing their water uptake rate and disintegrant performance. Different brands of Polacrilin Potassium NF differed in the abilities to withstand the effects of moisture on their functionality. Effect of moisture on disintegrant performance of Polacrilin Potassium NF needs to be considered before its use in tablets made by wet granulation.
Starting Page	24
Ending Page	34
Page Count	11
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	13
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2011-11-09
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Pharmacy Biotechnology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

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