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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sagiri, Sai S. Pal, Kunal Basak, Piyali Rana, Usman Ali Shakir, Imran Anis, Arfat |
| Copyright Year | 2014 |
| Abstract | Leaching of the internal apolar phase from the biopolymeric microparticles during storage is a great concern as it undoes the beneficial effects of encapsulation. In this paper, a novel formulation was prepared by encapsulating the sunflower oil-based organogels in alginate microparticles. Salicylic acid and metronidazole were used as the model drugs. The microparticles were prepared by double emulsion methodology. Physico-chemical characterization of the microparticles was done by microscopy, FTIR, XRD, and DSC studies. Oil leaching studies, biocompatibility, mucoadhesivity, in vitro drug release, and the antimicrobial efficiency of the microparticles were also performed. The microparticles were found to be spherical in shape. Gelation of the sunflower oil prevented leaching of the internal phase from the microparticles. Release of drugs from the microparticles followed Fickian kinetics and non-Fickian kinetics in gastric and intestinal environments, respectively. Microparticles showed good antimicrobial activity against both Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacteria. The results suggested that the developed formulations hold promise to carry oils without leakage of the internal phase. Encapsulation of organogels within the microparticles has improved the drug entrapment efficiency and improved characteristics for controlled delivery applications. |
| Starting Page | 1197 |
| Ending Page | 1208 |
| Page Count | 12 |
| File Format | |
| Journal | AAPS PharmSciTech |
| Volume Number | 15 |
| Issue Number | 5 |
| e-ISSN | 15309932 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2014-06-03 |
| Publisher Institution | American Association of Pharmaceutical Scientists |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pharmacology/Toxicology Biotechnology Biochemistry Pharmacy |
| Content Type | Text |
| Resource Type | Article |
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