NDLI: Development and Evaluation of Sustained-Release Etoposide-Loaded Poly(ε-Caprolactone) Implants

Content Provider	Springer Nature Link
Author	Sola, Ana Gabriela Reis Fátima Pereira, Adriana Pinto, Flavia Carmo Horta Ferreira, Letícia Gonçalves Resende Oliveira Barbosa, Leandro Augusto Fialho, Silvia Ligório Oliveira Patricio, Patrícia Santiago Silva Cunha, Armando Silva, Gisele Rodrigues Pianetti, Gérson Antônio
Copyright Year	2013
Abstract	Poly(ε-caprolactone) implants containing etoposide, an important chemotherapeutic agent and topoisomerase II inhibitor, were fabricated by a melt method and characterized in terms of content uniformity, morphology, drug physical state, and sterility. In vitro and in vivo drug release from the implants was also evaluated. The cytotoxic activity of implants against HeLa cells was studied. The short-term tolerance of the implants was investigated after subcutaneous implantation in mice. The original chemical structure of etoposide was preserved after incorporation into the polymeric matrix, in which the drug was dispersed uniformly. Etoposide was present in crystalline form in the polymeric implant. In vitro release study showed prolonged and controlled release of etoposide, which showed cytotoxicity activity against HeLa cells. After implantation, good correlation between in vitro and in vivo drug release was found. The implants demonstrated good short-term tolerance in mice. These results tend to show that etoposide-loaded implants could be potentially applied as a local etoposide delivery system.
Starting Page	890
Ending Page	900
Page Count	11
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	14
Issue Number	2
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2013-05-11
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Biotechnology Biochemistry Pharmacy
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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