NDLI: Tween-Embedded Microemulsions—Physicochemical and Spectroscopic Analysis for Antitubercular Drugs

Content Provider	Springer Nature Link
Author	Mehta, S. K. Kaur, Gurpreet Bhasin, K. K.
Copyright Year	2009
Abstract	The microemulsion composed of oleic acid, phosphate buffer, ethanol, and Tween (20, 40, 60, and 80) has been investigated in the presence of antitubercular drugs of extremely different solubilities, viz. isoniazid (INH), pyrazinamide (PZA), and rifampicin (RIF). The phase behavior showing the realm of existence of microemulsion has been delineated at constant surfactant/co-surfactant ratio (K $_{m}$ = 0.55) with maximum isotropic region resulting in the case of Tween 80. The changes in the microstructure of Tween 80-based microemulsion in the presence of anti-TB drugs have been established using conductivty (σ) and viscosity (η) behavior. The optical microscopic images of the system help in understanding the effect of dilution and presence of drug on the structure of microemulsion. Partition coefficient, particle size analysis, and spectroscopic studies (UV–visible, Fourier transform infrared, and $^{1}$H NMR) have been performed to evaluate the location of a drug in the colloidal formulation. To compare the release of RIF, PZA, and INH from Tween 80 formulation, the dissolution studies have been carried out. It shows that the release of drugs follow the order INH>PZA>RIF. The kinetics of the release of drug has been analyzed using the Korsmeyer and Peppas equation. The results have given a fair success to predict that the release of PZA and INH from Tween 80 microemulsion is non-Fickian, whereas RIF is found to follow a Fickian mechanism.
Starting Page	143
Ending Page	153
Page Count	11
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	11
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2010-01-20
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	isoniazid microemulsion pyrazinamide rifampicin solubility stability Tween Pharmacy Biochemistry Biotechnology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Incorporation of Antitubercular Drug Isoniazid in Pharmaceutically Accepted Microemulsion: Effect on Microstructure and Physical Parameters

Development and Evaluation of Lorazepam Microemulsions for Parenteral Delivery

Discovery pharmaceutics—Challenges and opportunities

A novel solid dosage form of rifampicin and isoniazid with improved functionality

Protective Effects of Kaempferol on Isoniazid- and Rifampicin-Induced Hepatotoxicity

Studies on toxicity of antitubercular drugs namely isoniazid, rifampicin, and pyrazinamide in an in vitro model of HepG2 cell line

Microemulsions Containing Medium-Chain Glycerides as Transdermal Delivery Systems for Hydrophilic and Hydrophobic Drugs

Preparation and physicochemical characterization of dioctyl sodium sulfosuccinate (aerosol OT) microemulsion for oral drug delivery

Development and validation of RP-HPLC method for simultaneous estimation of rifampicin, isoniazid and pyrazinamide in human plasma

Tween-Embedded Microemulsions—Physicochemical and Spectroscopic Analysis for Antitubercular Drugs

Similar Documents

Incorporation of Antitubercular Drug Isoniazid in Pharmaceutically Accepted Microemulsion: Effect on Microstructure and Physical Parameters

Development and Evaluation of Lorazepam Microemulsions for Parenteral Delivery

Discovery pharmaceutics—Challenges and opportunities

A novel solid dosage form of rifampicin and isoniazid with improved functionality

Protective Effects of Kaempferol on Isoniazid- and Rifampicin-Induced Hepatotoxicity

Studies on toxicity of antitubercular drugs namely isoniazid, rifampicin, and pyrazinamide in an in vitro model of HepG2 cell line

Microemulsions Containing Medium-Chain Glycerides as Transdermal Delivery Systems for Hydrophilic and Hydrophobic Drugs

Preparation and physicochemical characterization of dioctyl sodium sulfosuccinate (aerosol OT) microemulsion for oral drug delivery

Development and validation of RP-HPLC method for simultaneous estimation of rifampicin, isoniazid and pyrazinamide in human plasma

Tween-Embedded Microemulsions—Physicochemical and Spectroscopic Analysis for Antitubercular Drugs