NDLI: Templated Ultrathin Polyelectrolyte Microreservoir for Delivery of Bovine Serum Albumin: Fabrication and Performance Evaluation

Content Provider	Springer Nature Link
Author	Gupta, Girish K. Jain, Vikas Mishra, Prabhat Ranjan
Copyright Year	2011
Abstract	The aim of the study was to develop ultrathin polyelectrolyte microreservoir (UPM) using two combinations of synthetic/synthetic (S/s; poly(allylamine hydrochloride) (PAH)/sodium poly(styrenesulfonate)) and synthetic/natural (S/n; PAH/sodium alginate) polyelectrolytes over spherical porous CaCO$_{3}$ core particles (CP) followed by core removal and to evaluate its biocompatibility and integrity of loaded model protein bovine serum albumin (BSA). A novel process for synthesis of CP was developed to obtain maximum yield of monodisperse vaterite (spherical) polymorph. The prepared UPM was characterized for surface morphology, layer-by-layer growth, pay load efficiency, integrity of BSA, as well as viability and cell adhesion using murine J 774 macrophages (Φ). In vitro release profile revealed that both S/s and S/n UPM were able to provide sufficient diffusion barrier to release protein at physiological pH. It has been observed that S/n UPM are fully biocompatible due to obvious reason of using natural polymer. In a separate experiment, the S/s UPM surface was modified with pluronic F-68 to tune biocompatibility which provides evidences for safety and tolerability of the S/s UPM as well. In nutshell, the proposed system could successfully be used for the delivery of proteins, and moreover, the system can be tailored to impart desired properties at any stage of layering especially in terms of drug release and to retain the integrity of proteins.
Starting Page	344
Ending Page	353
Page Count	10
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	12
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2011-02-01
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	biocompatible cell adhesion electrostatic attraction layer-by-layer (LBL) assembly natural polyelectrolyte Pharmacology/Toxicology Pharmacy Biotechnology Biochemistry
Content Type	Text
Resource Type	Article

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