NDLI: Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

Content Provider	Springer Nature Link
Author	Just, Sarah Toschkoff, Gregor Funke, Adrian Djuric, Dejan Scharrer, Georg Khinast, Johannes Kp, Klaus Kleinebudde, Peter
Copyright Year	2013
Abstract	Coating of solid dosage forms is an important unit operation in the pharmaceutical industry. In recent years, numerical simulations of drug manufacturing processes have been gaining interest as process analytical technology tools. The discrete element method (DEM) in particular is suitable to model tablet-coating processes. For the development of accurate simulations, information on the material properties of the tablets is required. In this study, the mechanical parameters Young’s modulus, coefficient of restitution (CoR), and coefficients of friction (CoF) of gastrointestinal therapeutic systems (GITS) and of active-coated GITS were measured experimentally. The dynamic angle of repose of these tablets in a drum coater was investigated to revise the CoF. The resulting values were used as input data in DEM simulations to compare simulation and experiment. A mean value of Young’s modulus of 31.9 MPa was determined by the uniaxial compression test. The CoR was found to be 0.78. For both tablet–steel and tablet–tablet friction, active-coated GITS showed a higher CoF compared with GITS. According to the values of the dynamic angle of repose, the CoF was adjusted to obtain consistent tablet motion in the simulation and in the experiment. On the basis of this experimental characterization, mechanical parameters are integrated into DEM simulation programs to perform numerical analysis of coating processes.
Starting Page	402
Ending Page	411
Page Count	10
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	14
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2013-01-25
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	active film coating DEM simulation dynamic angle of repose tablet coating tablet mechanical properties Pharmacology/Toxicology Biotechnology Biochemistry Pharmacy
Content Type	Text
Resource Type	Article

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