NDLI: Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines

Please wait, while we are loading the content...

Retraction Note on: The Influence of Sodium Hyaluronate, l-Leucine and Sodium Taurocholate on the Nebulization of Aqueous Betamethasone-17-Valerate Suspensions

Nanoemulsion as a Potential Ophthalmic Delivery System for Dorzolamide Hydrochloride

A Two One-Sided Parametric Tolerance Interval Test for Control of Delivered Dose Uniformity. Part 1—Characterization of FDA Proposed Test

A Two One-Sided Parametric Tolerance Interval Test for Control of Delivered Dose Uniformity—Part 3—Investigation of Robustness to Deviations from Normality

A Two One-Sided Parametric Tolerance Interval Test for Control of Delivered Dose Uniformity—Part 2—Effect of Changing Parameters

Exploring the Potential of A Highly Compressible Microcrystalline Cellulose as Novel Tabletting Excipient in the Compaction of Extended-Release Coated Pellets Containing an Extremely Water-Soluble Model Drug

Studies on the Effect of Water-Soluble Polymers on Drug–Cyclodextrin Complex Solubility

Influence of an Acrylic Polymer Blend on the Physical Stability of Film-Coated Theophylline Pellets

Stability Studies of Microparticulate System with Piroxicam as Model Drug

Irreversible Electroporation for Microbial Control of Drugs in Solution

Multiunit Floating Drug Delivery System of Rosiglitazone Maleate: Development, Characterization, Statistical Optimization of Drug Release and In Vivo Evaluation

Amyloid-Beta Associated with Chitosan Nano-Carrier has Favorable Immunogenicity and Permeates the BBB

Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS)

Effect of Formulation Components on the In Vitro Permeation of Microemulsion Drug Delivery System of Fluconazole

FIP Position Paper on Qualification of Paddle and Basket Dissolution Apparatus

Microcapsules and Transdermal Patch: A Comparative Approach for Improved Delivery of Antidiabetic Drug

Nanoparticles of Polyethylene Sebacate: A New Biodegradable Polymer

Exploring the Effect of Hesperetin–HSPC Complex—A Novel Drug Delivery System on the In Vitro Release, Therapeutic Efficacy and Pharmacokinetics

A Novel Itraconazole Bioadhesive Film for Vaginal Delivery: Design, Optimization, and Physicodynamic Characterization

Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems: I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin

The Enhancing Effect of Ion-pairing on the Skin Permeation of Glipizide

In Situ Forming Formulation: Development, Evaluation, and Optimization Using 3$^{3}$ Factorial Design

Formulation and Evaluation of Lidocaine Lipid Nanosystems for Dermal Delivery

Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study

Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines

Enhanced Topical Delivery of Terbinafine Hydrochloride with Chitosan Hydrogels

Formulation of Dacarbazine-Loaded Cubosomes—Part I: Influence of Formulation Variables

Formulation of Dacarbazine-loaded Cubosomes—Part II: Influence of Process Parameters

The Application of Modified Flow-Through Cell Apparatus for the Assessment of Chlorhexidine Dihydrochloride Release from Lozenges Containing Sorbitol

Emulsifiers’ Composition Modulates Venous Irritation of the Nanoemulsions as a Lipophilic and Venous Irritant Drug Delivery System

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part II: Biological Evaluation

Formulation and Evaluation of Gastroretentive Drug Delivery System of Propranolol Hydrochloride

AAPS PharmSciTech : Volume 10, Issue 2, June 2009

AAPS PharmSciTech : Volume 10, Issue 1, March 2009

AAPS PharmSciTech : Volume 9

AAPS PharmSciTech : Volume 8

AAPS PharmSciTech : Volume 7

AAPS PharmSciTech : Volume 6

AAPS PharmSciTech : Volume 5

AAPS PharmSciTech : Volume 4

AAPS PharmSciTech : Volume 3

AAPS PharmSciTech : Volume 2

AAPS PharmSciTech : Volume 1

Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines

Content Provider	Springer Nature Link
Author	Spaniol, Bárbara Bica, Vinicius Claudi Ruppenthal, Lisias Rafael Volpato, Maria Ramos Petrovick, Pedro Ros
Copyright Year	2009
Abstract	The purpose of this paper was to evaluate the compressional behavior of granules containing high load of a Phyllanthus niruri spray-dried extract in eccentric (ETM) and rotary (RTM) tablet presses. Tablets were constituted by spray-dried extract granules (SDEG, 92%), excipient granules (EXCG, 7.92%), and magnesium stearate (0.08%). SDEG was obtained by dry granulation and EXCG, composed of microcrystalline cellulose (62.9%) and sodium starch glycolate (37.1%), by wet granulation. Particle size distribution was fixed between 0.250 and 0.850 mm. Tablets did not evidence any mechanical failures, such as lamination or capping, or anomalous weight variation in either tablet machine types. Upper and lower tablet surface photomicrographs from ETM and RTM tablets showed differences in porosity and texture. Different RTM speeds suggested the visco-plastic behavior of the formulation, since, by slowing down rotation speeds, the tensile strength of the tablets increased significantly, but the porosity and disintegration time were not affected. Tablets produced in RTM showed lower friability and porosity than ETM tablets, which did not reflect on higher tensile strength. The EXCG distribution at upper and lower surfaces from ETM and RTM tablets was quantified by image analysis and evaluated through statistical methods. Spray-dried extract release was not influenced by the type of equipment or operational conditions to which the compacts were submitted. Construction and operation differences between both tablet presses influenced the final product, since tablets with similar tensile strength, made by distinct tablet machines, exhibited different quality parameters.
Starting Page	1013
Ending Page	1023
Page Count	11
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	10
Issue Number	3
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2009-08-07
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	eccentric tablet machine image analysis Phyllanthus niruri rotary tablet machine spray-dried extract Pharmacy Biochemistry Biotechnology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines

Eudragit E as excipient for production of granules and tablets from phyllanthus niruri L spray-dried extract

Development of granules from Phyllanthus niruri spray-dried extract

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Development of granules from Phyllanthus niruri spray-dried extract

Optimization of tablets containing a high dose of spray-dried plant extract: A technical note

The 3-D model: Comparison of parameters obtained from and by simulating different tableting machines

Comparison of the Halving of Tablets Prepared with Eccentric and Rotary Tablet Presses

Spray-Dried Microparticles Containing Polymeric Micelles Encapsulating Hematoporphyrin

Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines

Similar Documents

Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines

Eudragit E as excipient for production of granules and tablets from phyllanthus niruri L spray-dried extract

Development of granules from Phyllanthus niruri spray-dried extract

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Development of granules from Phyllanthus niruri spray-dried extract

Optimization of tablets containing a high dose of spray-dried plant extract: A technical note

The 3-D model: Comparison of parameters obtained from and by simulating different tableting machines

Comparison of the Halving of Tablets Prepared with Eccentric and Rotary Tablet Presses

Spray-Dried Microparticles Containing Polymeric Micelles Encapsulating Hematoporphyrin

Compressional Behavior of a Mixture of Granules Containing High Load of Phyllanthus niruri Spray-Dried Extract and Granules of Adjuvants: Comparison between Eccentric and Rotary Tablet Machines