NDLI: In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride

Content Provider	Springer Nature Link
Author	Al Saidan, Saleh M. Krishnaiah, Yellela S. R. Patro, S. Satyanaryana, Vemulapalli
Copyright Year	2005
Abstract	The objective of the study was to develop guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. Matrix tablets of diltiazem hydrochloride, using various viscosity grades of guar gum in 2 proportions, were prepared by wet granulation method and subjected to in vitro drug release studies. Diltiazem hydrochloride matrix tablets containing either 30% wt/wt lowviscosity (LM1), 40% wt/wt medium-viscosity (MM2), or 50% wt/wt high-viscosity (HM2) guar gum showed controlled release. The drug release from all guar gum matrix tablets followed first-order kinetics via Fickian-diffusion. Further, the results of in vitro drug release studies in simulated gastrointestinal and colonic fluids showed that HM2 tablets provided controlled release comparable with marketed sustained release diltiazem hydrochloride tablets (D-SR tablets). Guar gum matrix tablets HM2 showed no change in physical appearance, drug content, or in dissolution pattern after storage at 40°C/relative humidity 75% for 6 months. When subjectd to in vivo pharmacokinetic evaluation in healthy volunteers, the HM2 tablets provided a slow and prolonged drug release when compared with D-SR tablets. Based on the results of in vitro and in vivo studies it was concluded that that guar gum matrix tablets provided oral controlled release of water-soluble diltiazem hydrochloride.
Starting Page	E14
Ending Page	E21
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	6
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-01-01
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	guar gum matrix tablets oral controlled release diltiazem hydrochloride in vitro drug release in vivo evaluation Biotechnology Biochemistry Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

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