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| Content Provider | Springer Nature Link |
|---|---|
| Author | Liu, Bin |
| Copyright Year | 2006 |
| Abstract | Parkinson’s disease (PD) is a debilitating movement disorder resulting from a progressive degeneration of the nigrostriatal dopaminergic pathway and depletion of neurotransmitter dopamine in the striatum. Molecular cloning studies have identified nearly a dozen genes or loci that are associated with small clusters of mostly early onset and genetic forms of PD. The etiology of the vast majority of PD cases remains unknown, and the precise molecular and biochemical processes governing the selective and progressive degeneration of the nigrostriatal dopaminergic pathway are poorly understood. Current drug therapies for PD are symptomatic and appear to bear little effect on the progressive neurodegenerative process. Studies of postmortem PD brains and various cellular and animal models of PD in the last 2 decades strongly suggest that the generation of proinflammatory and neurotoxic factors by the resident brain immune cells, microglia, plays a prominent role in mediating the progressive neurodegenerative process. This review discusses literature supporting the possibility of modulating the activity of microglia as a neuroprotective strategy for the treatment of PD. |
| Starting Page | E606 |
| Ending Page | E621 |
| File Format | |
| ISSN | 12341234 |
| Journal | The AAPS Journal |
| Volume Number | 8 |
| Issue Number | 3 |
| e-ISSN | 15507416 |
| Language | English |
| Publisher | Springer New York |
| Publisher Date | 2006-09-01 |
| Publisher Institution | American Association of Pharmaceutical Scientists |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Dopamine neuron Parkinson’s disease movement disorder microglia neuroprotection free radical Pharmacology/Toxicology Biochemistry Biotechnology Pharmacy |
| Content Type | Text |
| Resource Type | Article |
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