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| Content Provider | Springer Nature Link |
|---|---|
| Author | Qiao, Xue Ji, Shuai Yu, Si wang Lin, Xiong hao Jin, Hong wei Duan, Yao kai Zhang, Liang ren Guo, De an Ye, Min |
| Copyright Year | 2013 |
| Abstract | Licorice has been shown to affect the activities of several cytochrome P450 enzymes. This study aims to identify the key constituents in licorice which may affect these activities. Bioactivity assay was combined with metabolic profiling to identify these compounds in several complex licorice extracts. Firstly, the inhibition potencies of 40 pure licorice compounds were tested using an liquid chromatography/tandem mass spectrometry cocktail method. Significant inhibitors of human P450 isozymes 1A2, 2C9, 2C19, 2D6, and 3A4 were then selected for examination of their structural features by molecular docking to determine their molecular interaction with several P450 isozymes. Based on the present in vitro inhibition findings, along with our previous in vivo metabolic studies and the prevalence of individual compounds in licorice extract, we identified several licorice constituents, viz., liquiritigenin, isoliquiritigenin, together with seven isoprenylated flavonoids and arylcoumarins, which could be key components responsible for the herb–drug interaction between cytochrome P450 and licorice. In addition, hydrophilic flavonoid glycosides and saponins may be converted into these P450 inhibitors in vivo. These studies represent a comprehensive examination of the potential effects of licorice components on the metabolic activities of P450 enzymes. |
| Starting Page | 101 |
| Ending Page | 113 |
| Page Count | 13 |
| File Format | |
| ISSN | 12341234 |
| Journal | The AAPS Journal |
| Volume Number | 16 |
| Issue Number | 1 |
| e-ISSN | 15507416 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-11-20 |
| Publisher Institution | American Association of Pharmaceutical Scientists |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pharmacology/Toxicology Biochemistry Biotechnology Pharmacy |
| Content Type | Text |
| Resource Type | Article |
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