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| Content Provider | Springer Nature Link |
|---|---|
| Author | Williams, John Pandarinathan, Lakshmipathi Wood, Jodi Anne Vouros, Paul Makriyannis, Alexandros |
| Copyright Year | 2006 |
| Abstract | We have synthesized 4,4-dimethoxyoxazoline derivatives of several fatty acids associated with the endocannabinoid metabolome using tris(hydroxymethyl)aminomethane in a 1-step reaction by microwave irradiation. The derivatization incorporates a nitrogen into the final product, which allows for improved detection by liquid chromatographymass spectrometry in positive atmospheric pressure chemical ionization (APCI) mode. Palmitic and oleic acid derivatives show a 200-fold increase in sensitivity compared with the free acids when analyzed in negative-mode APCI. In addition to improving sensitivity, the oxazoline derivatization creates a similar ionization response for the fatty acids tested, which simplifies their quantitation. Fatty acid oxazoline derivatives can be detected using the same conditions optimized for the endocannabinoids, which allows for a simultaneous quantitation of the entire endocannabinoid metabolome. |
| Starting Page | E655 |
| Ending Page | E660 |
| File Format | |
| ISSN | 12341234 |
| Journal | The AAPS Journal |
| Volume Number | 8 |
| Issue Number | 4 |
| e-ISSN | 15507416 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2006-01-01 |
| Publisher Institution | American Association of Pharmaceutical Scientists |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | fatty acids LC-MS metabolome oxazoline derivatives microwave synthesis Pharmacy Pharmacology/Toxicology Biotechnology |
| Content Type | Text |
| Resource Type | Article |
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