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The AAPS Journal : Volume 1

Maturation and growth of renal function: Dosing renally cleared drugs in children

Content Provider	Springer Nature Link
Author	Hayton, William L.
Copyright Year	2002
Abstract	A model was developed that characterized the maturation and growth of the renal function parameters (RFPs) glomerular filtration rate (GF), active tubular secretion (AS), and renal plasma flow (Q$_{R}$). Published RFP values were obtained from 63 healthy children between the ages of 2 days and 12 years. Maturation over time was assumed to be exponential from an immature (RFP$_{im}$) to a mature (RFP$_{ma}$) level; for growth, RFP$_{im}$ and RFP$_{ma}$ were assumed to follow the allometric equation: RFP(age, W)=aW$^{b}$e$^{−kmat}$ $^{}$age+cW$^{b}$(1−e$^{−kmat}$ $^{}$age), where W is body weight, k$_{mat}$ is the maturation rate constant, b is the body weight exponent, and a and c are RFP$_{im}$ and RFP$_{ma}$ at unit W. The model-based equation was fitted to the age-W, RFP values by a nonlinear least-squares method. For GF, the maturation half-life was 7.9 months (90% maturation, 26 months), the body weight exponent was 0.662, and the ratio c/a (which reflected the magnitude of the maturation influence) was 3.1. For AS and Q$_{R}$, the maturation half-lives were about 3.8 months and the ratio c/a was about 1.8. For renally eliminated drugs, the model can be used to estimate dosing regimens that are based on the adult dosing regimen and the age and weight of the child.
Starting Page	22
Ending Page	28
Page Count	7
File Format	PDF
ISSN	12341234
Journal	The AAPS Journal
Volume Number	2
Issue Number	1
e-ISSN	15221059
Language	English
Publisher	Springer New York
Publisher Date	2000-03-01
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Pharmacology/Toxicology Biochemistry Biotechnology Pharmacy
Content Type	Text
Resource Type	Article

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