NDLI: Cannabinoids, electrophysiology, and retrograde messengers: Challenges for the next 5 years

Content Provider	Springer Nature Link
Author	Straiker, Alex Mackie, Ken
Copyright Year	2006
Abstract	Most of the behavioral effects of cannabis and its active ingredients, the cannabinoids (Δ$^{9}$THC being the most abundant of these), appear to be mediated by cannabinoid receptors. Endogenous cannabinoids (endocannabinoids) are lipid mediators that activate these same cannabinoid receptors. Elegant work from several laboratories over the past 5 years has established that endocannabinoids, possibly acting as retrograde messengers, mediate several forms of neuronal plasticity. Endocannabinoid-mediated neuronal plasticity is common, apparently occurring at all neurons that express cannabinoid receptors. Thus, it is likely that, Δ$^{9}$THC produces its effects by interacting with endocannabinoidmediated neuronal plasticity, though whether it does so cooperatively or antagonistically remains an open question. In this review we will briefly discuss the work establishing endocannabinoids as mediators of neuronal plasticity and then present evidence that a major effect of Δ$^{9}$THC may be to antagonize the actions of endocannabinoids.
Starting Page	E272
Ending Page	E276
File Format	PDF
ISSN	12341234
Journal	The AAPS Journal
Volume Number	8
Issue Number	2
e-ISSN	15507416
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	neuronal plasticity endocannabinoid longterm depression calcium cannabis Pharmacology/Toxicology Biochemistry Biotechnology Pharmacy
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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