NDLI: Reducing Energy Consumption in Pharmaceutical Production Processes: Framework and Case Study

Content Provider	Springer Nature Link
Author	Müller, Georg Sugiyama, Hirokazu Stocker, Simon Schmidt, Rainer
Copyright Year	2014
Abstract	This paper aims to present a novel framework for reducing energy consumption in pharmaceutical manufacturing processes, with a primary focus on parenterals production. The framework supports (a) the design of optimal energy-saving solutions, (b) the execution and implementation and (c) the comparison of designed and actual performance as a post-implementation control. In selecting promising options, multiobjective criteria are defined for comprehensive decision-making which considers not only energy savings, but also other aspects such as good manufacturing practice (GMP), risk, and workers’ safety.In the framework, five phases were defined in total, with three for design and two for execution and control, respectively. In the three design phases, options are generated, evaluated and selected step by step, with appropriate evaluation criteria covering financial as well as non-financial aspects. The roles of various stakeholders, e.g., Operations, Engineering, or Quality Assurance, are defined for each phase in order to enable smooth and certain decision-making.A case study was performed in the parenterals production plant at Hoffmann-La Roche in Kaiseraugst. Twelve energy efficiency ideas were generated and, after the screening and selection process, the three most promising options from the multiobjective Pareto optimization were implemented to reduce the total plant’s energy consumption by 2.5 %.The framework enabled the systematic generation and selection of various options, which helped in the allocation of company resources in a prioritized and thus effective manner.
Starting Page	212
Ending Page	226
Page Count	15
File Format	PDF
ISSN	18725120
Journal	Journal of Pharmaceutical Innovation
Volume Number	9
Issue Number	3
e-ISSN	19398042
Language	English
Publisher	Springer US
Publisher Date	2014-07-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Energy efficiency Pharmaceutical manufacturing Multiobjective decision-making Parenterals production Industrial case study Pharmacology/Toxicology Industrial and Production Engineering Biotechnology Biochemical Engineering
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Pharmaceutical Manufacturing Innovation

Analysis of Manufacturing Costs in Pharmaceutical Companies

Editorial: Speed and Efficiency in Pharmaceutical Development

Purdue Ontology for Pharmaceutical Engineering: Part I. Conceptual Framework

Loss-in-Weight Feeding Trials Case Study: Pharmaceutical Formulation

Leveraging Bayesian Approach to Predict Drug Manufacturing Performance

Toward intelligent decision support for pharmaceutical product development

Decision-Support Method for the Choice Between Single-Use and Multi-Use Technologies in Sterile Drug Product Manufacturing

QbD—Enabling Modern Product Development and Manufacturing

Reducing Energy Consumption in Pharmaceutical Production Processes: Framework and Case Study

Similar Documents

Pharmaceutical Manufacturing Innovation

Analysis of Manufacturing Costs in Pharmaceutical Companies

Editorial: Speed and Efficiency in Pharmaceutical Development

Purdue Ontology for Pharmaceutical Engineering: Part I. Conceptual Framework

Loss-in-Weight Feeding Trials Case Study: Pharmaceutical Formulation

Leveraging Bayesian Approach to Predict Drug Manufacturing Performance

Toward intelligent decision support for pharmaceutical product development

Decision-Support Method for the Choice Between Single-Use and Multi-Use Technologies in Sterile Drug Product Manufacturing

QbD—Enabling Modern Product Development and Manufacturing

Reducing Energy Consumption in Pharmaceutical Production Processes: Framework and Case Study