NDLI: Differences in proteolytic activity and gene profiles of fungal strains isolated from the total parenteral nutrition patients

Content Provider	Springer Nature Link
Author	Sikora, M. Dabkowska, M. Swoboda Kopec, E. Jarzynka, S. Netsvyetayeva, I. Jaworska Zaremba, M. Pertkiewicz, M. Mlynarczyk, G.
Copyright Year	2011
Abstract	Fungal infections constitute a serious clinical problem in the group of patients receiving total parenteral nutrition. The majority of species isolated from infections of the total parenteral nutrition patients belong to Candida genus. The most important factors of Candida spp. virulence are the phenomenon of “phenotypic switching,” adhesins, dimorphism of fungal cells and the secretion of hydrolytic enzymes such as proteinases and lipases, including aspartyl proteinases. We determined the proteolytic activity of yeast-like fungal strains cultured from the clinical materials of patients receiving total parenteral nutrition and detected genes encoding aspartyl proteinases in predominant species Candida glabrata—YPS2, YPS4, and YPS6, and Candida albicans—SAP1–3, SAP4, SAP5, and SAP6. C. albicans released proteinases on the various activity levels. All C. glabrata strains obtained from the clinical materials of examined and control groups exhibited secretion of the proteinases. All 13 isolates of C. albicans possessed genes SAP1–3. Gene SAP4 was detected in genome of 11 C. albicans strains, SAP5 in 6, and SAP6 in 11. Twenty-six among 31 of C. glabrata isolates contained YPS2 gene, 21 the YPS4 gene, and 28 the YPS6 gene. We observed that clinical isolates of C. albicans and C. glabrata differed in SAPs and YPSs gene profiles, respectively, and displayed differentiated proteolytic activity. We suppose that different sets of aspartyl proteinases genes as well as various proteinase-activity levels would have the influence on strains virulence.
Starting Page	143
Ending Page	148
Page Count	6
File Format	PDF
ISSN	00155632
Journal	Folia Microbiologica
Volume Number	56
Issue Number	2
e-ISSN	18749356
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-04-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Environmental Engineering/Biotechnology Applied Microbiology Life Sciences Immunology Microbiology
Content Type	Text
Resource Type	Article
Subject	Medicine Microbiology

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