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| Content Provider | Springer Nature Link |
|---|---|
| Author | Birteksöz Tan, Ayşe Seher Zeybek, Zuhal |
| Copyright Year | 2012 |
| Abstract | The postantibiotic effects (PAE) of azithromycin, clarithromycin, ciprofloxacin, and levofloxacin were investigated against Legionella pneumophila (L. pneumophila) strains isolated from several hot water systems of different buildings in Istanbul. Each strain in logarithmic phase of growth was exposed to concentrations of antibiotics equal to minimum inhibitory concentration (MIC) and 4× MIC for 1 h. Recovery periods of test cultures were evaluated after centrifugation using the viable counting method. The mean values of PAEs for the strains of L. pneumophila, azithromycin at a concentration equal to and 4 times of MIC values were found 1.75 ± 0.28 h and 4.06 ± 0.44 h, for clarithromycin 2.98 ± 0.70 h and 4.18 ± 0.95 h, for ciprofloxacin 2.97 ± 0.63 h and 4.70 ± 0.63 h, for levofloxacin 2.05 ± 0.33 h and 3.78 ± 0.46 h, respectively. All of the antibiotics showed increased PAE values in a concentration-dependent manner. The findings of our study may play useful role in selecting the appropriate timing of doses during therapy with antimicrobials to treat patients infected with L. pneumophila. |
| Starting Page | 495 |
| Ending Page | 499 |
| Page Count | 5 |
| File Format | |
| ISSN | 00155632 |
| Journal | Folia Microbiologica |
| Volume Number | 57 |
| Issue Number | 6 |
| e-ISSN | 18749356 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-05-25 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Immunology Environmental Engineering/Biotechnology Microbiology Applied Microbiology Life Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Microbiology |
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