NDLI: Effect ofDaucus carota var.boissieri extracts on immune response ofSchistosoma mansoni infected mice

Content Provider	Springer Nature Link
Author	Shalaby, N. M. M. Maghraby, A. S. El Hagrassy, A. M.
Copyright Year	1999
Abstract	Isolation and structure elucidation was carried out of flavonoid constituents found in fractionated extracts of the seeds and green leaves ofDaucus carota L. var.boissieri (Apiaceae). The flavonoids are mainly apigenin luteolin, their glycosidic precursors and 2,4,5-trimethoxybenzaldehyde. Fatty acids, hydrocarbons and sterols were identified by GLC. The effect of various carrot extracts on the immune responses ofSchistosoma mansoni infected mice was studied. The rate of reduction in worm infestation in mice injected with some fractions indicated a strong protection. Some extracts induced humoral immune response through raising the IgG level at 2, 4 and 6 weeks post-infection as compared with infected control. The phenotypic analysis of the cellular immune response in spleen and mesenteric lymph nodes was accomplished by direct immunofluorescence. The data showed that some extracts stimulated the blastogenesis of CD4$^{+}$-T splenocytes and mesenteric lymph node cells.
Starting Page	441
Ending Page	448
Page Count	8
File Format	PDF
ISSN	00155632
Journal	Folia Microbiologica
Volume Number	44
Issue Number	4
e-ISSN	18749356
Language	English
Publisher	Springer Netherlands
Publisher Date	1999-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Life Sciences Microbiology Applied Microbiology Immunology Environmental Engineering/Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Microbiology

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