NDLI: Fabrication of silk fibroin based three dimensional scaffolds for tissue engineering

Content Provider	Springer Nature Link
Author	Yin, C. Jatoi, A. W. Bang, H. Gopiraman, M. Kim, I. S.
Copyright Year	2016
Abstract	Herein we report successful synthesis of silk fibroin (SF) three dimensional scaffolds (SF 3D-scaffold) from SF sponge and SF nanofibers. Both the nanofibers and sponge were prepared from Bombyx mori fibroin. The SF 3D-scaffold was prepared by electrospinning the fibroin nanofibers over the sponge. Surface morphology was determined by scanning electron microscopy (SEM), while nanofiber diameter and pore size were measured using imageJ software. Effect of spinning time on the pore size and cell adhesion was determined. Average diameter of the SF nanofibers was measured to be 320 nm and pore size was found to reduce with increasing spinning time, such that, for 1 h spinning time pore size was 231 µm and the same for 3.5 h was 4.1 µm. However, the number of pores increased with spinning time. The results confirmed adhesion of MC3T3-E1 cells on the SF sponge, SF nanofibers and SF three dimensional scaffolds. Higher cell adhesion was found on the three dimensional scaffold in comparison to the nanofibers and sponge, possibly due to highly porous structure with very small and numerous pores in the resultant composite; hence more cell adhesion sites. The cell adhesion result confirmed biocompatibility of the SF 3D-scaffold and hence its suitability for applications in tissue engineering.
Starting Page	1140
Ending Page	1145
Page Count	6
File Format	PDF
ISSN	12299197
Journal	Fibers and Polymers
Volume Number	17
Issue Number	8
e-ISSN	18750052
Language	English
Publisher	The Korean Fiber Society
Publisher Date	2016-08-27
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Electrospinning Nanofibers Silk fibroin 3D-scaffold Biocompatibility Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering Polymers and Plastics

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