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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yang, Liu Ji, Jing Li, Guanghui Li, Junwen Chen, Zhaoli Wang, Haiyong |
| Copyright Year | 2014 |
| Abstract | Aflatoxins are the most popular hepatotoxicants. Chronic exposure to aflatoxins leads to a wide variety of liver diseases, such as hepatocellular carcinoma. In this study, we analyzed the genome wide expression profiles of aflatoxin B1-induced rat hepatic epithelial cells. The expression of 325, 184 and 199 special genes was altered when exposed to 0.03, 0.1 and 0.2 μmol/L aflatoxin B1 respectively, and 239 genes were commonly expressed. After the functional analysis on these dose-special genes, we determined several key pathways related to hepatotoxicity, such as TGF-beta signaling pathway, tight junction, adherens junction, the regulation of actin cytoskeleton, ErbB signaling pathway, p53 signaling pathway, pathways in cancer and axon guidance. Common genes were mainly associated with focal adhesion, ECM-receptor interaction, and cell adhesion molecules. Gene ontology annotations showed a good concordance with these pathways. The quantitative real-time polymerase chain reaction(PCR) analysis of selected genes showed similar patterns in microarrays. The toxicogenomic study provides a better understanding of molecular mechanisms of aflatoxins. |
| Starting Page | 451 |
| Ending Page | 457 |
| Page Count | 7 |
| File Format | |
| ISSN | 10064982 |
| Journal | Transactions of Tianjin University |
| Volume Number | 20 |
| Issue Number | 6 |
| e-ISSN | 19958196 |
| Language | English |
| Publisher | Tianjin University |
| Publisher Date | 2014-12-07 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | aflatoxin microarray gene ontology Kyoto encyclopedia of genes and genomes(KEGG) pathway hepatotoxicity Mechanical Engineering Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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