NDLI: Characterization of the Concentration-Dependence of Solute Diffusivity and Partitioning in a Model Dextran

Content Provider	Springer Nature Link
Author	Albro, Michael B. Rajan, Vikram Li, Roland Hung, Clark T. Ateshian, Gerard A.
Copyright Year	2009
Abstract	This study reports experimental measurements of solute diffusivity and partition coefficient for various solute concentrations and gel porosities, and proposes novel constitutive relations to describe these observed values. The longer-term aim is to explore the theoretical ramifications of accommodating variations in diffusivity and partition coefficient with solute concentration and tissue porosity, and investigate whether they might suggest novel mechanisms not previously recognized in the field of solute transport in deformable porous media. The study implements a model transport system of agarose hydrogels to investigate the effect of solute concentration and hydrogel porosity on the transport of dextran polysaccharides. The proposed phenomenological constitutive relations are shown to provide better fits of experimental results than prior models proposed in the literature based on the microstructure of the gel. While these constitutive models were developed for the transport of dextran in agarose hydrogels, it is expected that they may also be applied to the transport of similar molecular weight solutes in other porous media. This quantification can assist in the application of biophysical models that describe biological transport in deformable tissues, as well as the cell cytoplasm.
Starting Page	295
Ending Page	305
Page Count	11
File Format	PDF
ISSN	18655025
Journal	Cellular and Molecular Bioengineering
Volume Number	2
Issue Number	3
e-ISSN	18655033
Language	English
Publisher	Springer US
Publisher Date	2009-08-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Agarose Dextran Diffusivity Partition coefficient Solute concentration dependence Transport hindrance Cell Biology Biomaterials Biophysics and Biological Physics Continuum Mechanics and Mechanics of Materials Mechanics Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Modeling and Simulation

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