NDLI: Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

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Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

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Cell Stress and Chaperones : Volume 18, Issue 1, January 2013

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Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

Content Provider	Springer Nature Link
Author	Gruden, Gabriella Carucci, Patrizia Lolli, Valentina Cosso, Loretta Dellavalle, Erika Rolle, Emanuela Cantamessa, Alessandro Pinach, Silvia Abate, Maria Lorena Campra, Donata Brunello, Franco Bru, Graziella Rizzetto, Mario Perin, Paolo Cavallo
Copyright Year	2012
Abstract	Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80 % with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p < 0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, log-sHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCV-related liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC.
Starting Page	235
Ending Page	241
Page Count	7
File Format	PDF
ISSN	13558145
Journal	Cell Stress and Chaperones
Volume Number	18
Issue Number	2
e-ISSN	14661268
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-17
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Heat shock protein 27 Hepatocellular carcinoma Liver cirrhosis Hepatitis C virus Biomedicine general Cell Biology Biochemistry Immunology Cancer Research Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry

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Serum heat shock protein 27 levels in patients with hepatocellular carcinoma.

Serum levels of heat shock protein 27 in patients with acute ischemic stroke

Serum levels of anti-heat shock protein 27 antibodies in patients with chronic liver disease.

Heat shock protein 70 (Hsp70) serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma

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Serum heat shock protein 27 levels in patients with hepatocellular carcinoma

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Serum heat shock protein 27 levels in patients with hepatocellular carcinoma