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Cell Stress and Chaperones : Volume 17, Issue 5, September 2012

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Cell Stress and Chaperones : Volume 17, Issue 1, January 2012

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Heat shock factor 1 is inactivated by amino acid deprivation

Content Provider	Springer Nature Link
Author	Hensen, Sanne M. M. Heldens, Lonneke Enckevort, Chrissy M. W. Genesen, Siebe T. Pruijn, Ger J. M. Lubsen, Nicolette H.
Copyright Year	2012
Abstract	Mammalian cells respond to a lack of amino acids by activating a transcriptional program with the transcription factor ATF4 as one of the main actors. When cells are faced with cytoplasmic proteotoxic stress, a quite different transcriptional response is mounted, the heat shock response, which is mediated by HSF1. Here, we show that amino acid deprivation results in the inactivation of HSF1. In amino acid deprived cells, active HSF1 loses its DNA binding activity as demonstrated by EMSA and ChIP. A sharp decrease in the transcript level of HSF1 target genes such as HSPA1A (Hsp70), DNAJB1 (Hsp40), and HSP90AA1 is also seen. HSPA1A mRNA, but not DNAJB1 mRNA, was also destabilized. In cells cultured with limiting leucine, HSF1 activity also declined. Lack of amino acids thus could lead to a lower chaperoning capacity and cellular frailty. We show that the nutrient sensing response unit of the ASNS gene contains an HSF1 binding site, but we could not detect binding of HSF1 to this site in vivo. Expression of either an HSF1 mutant lacking the activation domain (HSF379) or an HSF1 mutant unable to bind DNA (K80Q) had only a minor effect on the transcript levels of amino acid deprivation responsive genes.
Starting Page	743
Ending Page	755
Page Count	13
File Format	PDF
ISSN	13558145
Journal	Cell Stress and Chaperones
Volume Number	17
Issue Number	6
e-ISSN	14661268
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-07-14
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Heat shock factor 1 Amino acid deprivation HSPA1A Stress response Neurosciences Cancer Research Biochemistry Cell Biology Biomedicine general Immunology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry

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Heat shock factor 1 is inactivated by amino acid deprivation

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ORIGINAL PAPER Heat shock factor 1 is inactivated by amino acid deprivation

Heat shock factor 1 is inactivated by amino acid deprivation

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