NDLI: T cell recognition of naturally presented epitopes of self-heat shock protein 70

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T cell recognition of naturally presented epitopes of self-heat shock protein 70

Content Provider	Springer Nature Link
Author	Jong, Huib Koffeman, Eva C. Meerding, Jennifer M. Scholman, Rianne C. Wieten, Lotte Jager, Wilco Klein, Mark Otten, Henny Wijk, Femke Zee, Ruurd Bijlsma, Johannes W. J. Broere, Femke Eden, Willem Prakken, Berent J.
Copyright Year	2014
Abstract	Self-reactive T cells have shown to have a potential role as regulators of the immune system preventing or even suppressing autoimmunity. One of the most abundant proteins that can be eluted from human HLA molecules is heat shock protein 70 (HSP70). The aims of the current study are to identify HSP70 epitopes based on published HLA elution studies and to investigate whether T cells from healthy individuals may respond to such self-epitopes. A literature search and subsequent in silico binding prediction based on theoretical MHC binding motifs resulted in the identification of seven HSP70 epitopes. PBMCs of healthy controls proliferated after incubation with two of the seven peptides (H167 and H290). Furthermore H161, H290, and H443 induced CD69 expression or production of cytokines IFNγ or TNFα in healthy controls. The identification of these naturally presented epitopes and the response they elicit in the normal immune system make them potential candidates to study during inflammatory conditions as well as in autoimmune diseases.
Starting Page	569
Ending Page	578
Page Count	10
File Format	PDF
ISSN	13558145
Journal	Cell Stress and Chaperones
Volume Number	19
Issue Number	4
e-ISSN	14661268
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-15
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Heat shock protein 70 HSP70 Naturally processed T cell epitopes Human HSP70 peptides Autoreactive T cells Biomedicine general Cell Biology Biochemistry Immunology Cancer Research Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry

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T cell recognition of naturally presented epitopes of self-heat shock protein 70.

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T cell recognition of naturally presented epitopes of self-heat shock protein 70.

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