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Cell Stress and Chaperones : Volume 15, Issue 5, September 2010

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Cell Stress and Chaperones : Volume 15, Issue 3, May 2010

Cell Stress and Chaperones : Volume 15, Issue 2, March 2010

Cell Stress and Chaperones : Volume 15, Issue 1, January 2010

Cell Stress and Chaperones : Volume 14

Cell Stress and Chaperones : Volume 13

Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis

Content Provider	Springer Nature Link
Author	Rodolico, Vito Tomasello, Giovanni Zerilli, Monica Martorana, Anna Pitruzzella, Alessandro Mari Gammazza, Antonella David, Sabrina Zummo, Giovanni Damiani, Provvidenza Accomando, Salvatore Conway de Macario, Everly Macario, Alberto J. L. Cappello, Francesco
Copyright Year	2010
Abstract	The purpose of this work was to determine in colon mucosa of Crohn’s disease (CD) and ulcerative colitis (UC) in relapse: a) the levels of the chaperonins Hsp60 and Hsp10; b) the quantity of inflammatory cells; and c) if the levels of chaperonins parallel those of inflammation cells. Twenty cases of CD and UC and twenty normal controls (NC) were studied using immunohistochemistry, Western blotting and immunofluorescence. Immunohistochemically, Hsp60 and Hsp10 were increased in both inflammatory bowel diseases (IBD) compared to NC. These results were confirmed by Western blotting. Hsp60 and Hsp10 occurred in the cytoplasm of epithelial cells in CD and UC but not in NC. Hsp60 and Hsp10 co-localised to epithelial cells of mucosal glands but not always in connective tissue cells of lamina propria, where only Hsp60 or, less often, Hsp10 was found. Cells typical of inflammation were significantly more abundant in CD and UC than in NC. Since chaperonins are key factors in the activation of the immune system leading to inflammation, we propose that they play a central role in the pathogenesis of the two diseases, which, consequently, ought to be studied as chaperonopathies.
Starting Page	877
Ending Page	884
Page Count	8
File Format	PDF
ISSN	13558145
Journal	Cell Stress and Chaperones
Volume Number	15
Issue Number	6
e-ISSN	14661268
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-04-15
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Chaperonins Inflammation IBD Chaperonopathies Autoimmunity Cancer Research Immunology Biochemistry Cell Biology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry

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Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis.

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