NDLI: Simultaneous Determination of Cyadox and Its Metabolites in Chicken Tissues by LC-MS/MS

Content Provider	Springer Nature Link
Author	Yan, Dandan He, Limin Zhang, Guijun Fang, Binghu Yong, Yan Li, Ying
Copyright Year	2012
Abstract	A specific and sensitive LC-MS/MS method was firstly established for the simultaneous extraction and determination of cyadox and its three main metabolites—1,4-bisdesoxycyadox, 4-desoxycyadox, and quinoxaline-2-carboxylic acid—in chicken muscle, liver, kidney, and fat tissues. Samples were subjected to extraction using ethyl acetate and followed by acetonitrile–chloroform (1:4, v/v) and further purified by Oasis mixed mode anion exchange SPE cartridge. Analysis was performed on a C$_{18}$ column by detection with MS in multiple-reaction monitoring mode. A gradient elution program with 0.1 % formic acid solution, acetonitrile, and 1 % formic acid (adjusted to pH 8 with ammonia) was performed at a flow rate of 0.2 mL min$^{−1}$. The correlation coefficients (r) for each calibration curve are higher than 0.99 within the experimental concentration range. The recoveries of the four target analytes at three spiking levels of 2.5, 25 and 250 μg kg$^{−1}$ were between 74.5 and 93.8 %, with relative standard deviations less than 12 %. The decision limits (CCαs) of the four analytes in chicken edible tissues ranged from 0.3 to 1.5 μg kg$^{−1}$, and the detection capabilities (CCβs) were below 2.3 μg kg$^{−1}$. The developed method demonstrated a satisfactory applicability in incurred chicken tissue samples.
Starting Page	1497
Ending Page	1505
Page Count	9
File Format	PDF
ISSN	19369751
Journal	Food Analytical Methods
Volume Number	5
Issue Number	6
e-ISSN	1936976X
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-04-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cyadox Metabolites High-performance liquid chromatography tandem mass spectrometry Chicken edible tissues Analytical Chemistry Chemistry/Food Science Microbiology Food Science
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Safety Research Safety, Risk, Reliability and Quality Applied Microbiology and Biotechnology Food Science

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