NDLI: Cytomegalovirus Disease in Renal Transplant Recipients: A Single-Center Experience

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Cytomegalovirus Disease in Renal Transplant Recipients: A Single-Center Experience

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Indian Journal of Microbiology : Volume 52, Issue 2, June 2012

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Cytomegalovirus Disease in Renal Transplant Recipients: A Single-Center Experience

Content Provider	Springer Nature Link
Author	Bhadauria, Dharmendra Sharma, R. K. Kaul, A. Prasad, Narayan Gupta, Amit Gupta, Anurag Srivastava, Aneesh
Copyright Year	2012
Abstract	Cytomegalovirus (CMV) is the most common viral infection following kidney transplant, has been recognized as a major factor for graft loss and increased incidence of acute rejection. Different studies have reported a variable incidence of CMV disease with the use of Mycophenolate mofetil (MMF). We retrospectively analyzed our renal transplant recipients to review the results of CMV disease and to compare CMV disease in patient on Azathioprine and MMF for this purpose we retrospectively reviewed 521 live related kidney transplant recipients at our institute. 74 (14.2 %) live related allograft recipients developed CMV disease after a median interval of 7.18 ± 4.35 months from transplantation. The mean age was 36.15 ± 10.7 years. 63 of the patients were male. Malaise, fever and diarrhea were among most common symptoms. 20 (27.02 %) of the 74 recipients developed transaminitis, 13 (17.2 %) developed CMV gastritis, 5 (9.13 %) recipients developed pneumonia, and 3 (4.05 %) patient developed colitis. 59 (80 %) patients had leucopenia and 41 (56.5 %) developed thrombocytopenia. Mean serum creatinine level was 1.5 ± 0.4 (0.9–2.4) mg/dl before the disease, 1.9 ± 0.6 (1.3–3.6) mg/dl at the time of the diagnosis, and 1.7 ± 0.06 (0.8–4.2) mg/dl at the end of the treatment. CMV disease developed in 9 (36 %) of recipients who received basiliximab as induction therapy and 13 (30.24 %) of recipients who received ATG (p > 0.05). The incidence of CMV disease was similar in cyclosporine based regimen (13.2 %) and Tacrolimus based regimen 27 (16.16 %) (p = 0.137) and was also similar in Azathioprine 41 (9.5 %) and MMF group 33 (14.3 %) (p = 0.163). There was no significant difference in severity of CMV disease in both groups, except a higher incidence of leucopenia in Azathioprine group (86 vs. 74 %, p < 0.05) as compared to MMF group. 51 (68.91 %) patient developed graft dysfunction during CMV disease. In conclusion we report a low incidence (14.2 %) and milder form of cytomegalovirus disease at our center. Use of universal cytomegalovirus prophylaxis was associated with a low incidence and milder form of the disease. Incidence of CMV disease was similar between Azathioprine and MMF groups.
Starting Page	510
Ending Page	515
Page Count	6
File Format	PDF
ISSN	00468991
Journal	Indian Journal of Microbiology
Volume Number	52
Issue Number	3
e-ISSN	09737715
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-04-04
Publisher Institution	Association of Microbiologists of India
Publisher Place	India
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cytomegalovirus CMV Renal allograft recipient Medical Microbiology Microbiology
Content Type	Text
Resource Type	Article
Subject	Microbiology

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