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  1. Journal of Cell Communication and Signaling
  2. Journal of Cell Communication and Signaling : Volume 3
  3. Journal of Cell Communication and Signaling : Volume 3, Issue 3-4, December 2009
  4. SPARC: a matricellular regulator of tumorigenesis
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Journal of Cell Communication and Signaling : Volume 11
Journal of Cell Communication and Signaling : Volume 10
Journal of Cell Communication and Signaling : Volume 9
Journal of Cell Communication and Signaling : Volume 8
Journal of Cell Communication and Signaling : Volume 7
Journal of Cell Communication and Signaling : Volume 6
Journal of Cell Communication and Signaling : Volume 5
Journal of Cell Communication and Signaling : Volume 4
Journal of Cell Communication and Signaling : Volume 3
Journal of Cell Communication and Signaling : Volume 3, Issue 3-4, December 2009
Matricellular proteins: an overview
The role of astrocyte-secreted matricellular proteins in central nervous system development and function
The interaction of Thrombospondins with extracellular matrix proteins
Thrombospondins function as regulators of angiogenesis
Thrombospondins in the heart: potential functions in cardiac remodeling
The role of thrombospondins in wound healing, ischemia, and the foreign body reaction
Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling
The role of SPARC in extracellular matrix assembly
SPARC functions as an inhibitor of adipogenesis
SPARC: a matricellular regulator of tumorigenesis
The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology
The role of tenascin-C in tissue injury and tumorigenesis
The role of osteopontin in inflammatory processes
The matricellular functions of small leucine-rich proteoglycans (SLRPs)
Fibulin-5, an integrin-binding matricellular protein: its function in development and disease
Journal of Cell Communication and Signaling : Volume 3, Issue 2, June 2009
Journal of Cell Communication and Signaling : Volume 3, Issue 1, March 2009
Journal of Cell Communication and Signaling : Volume 2
Journal of Cell Communication and Signaling : Volume 1

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SPARC: a matricellular regulator of tumorigenesis

Content Provider Springer Nature Link
Author Arld, Shanna A. Brekken, Rolf A.
Copyright Year 2009
Abstract Although many clinical studies have found a correlation of SPARC expression with malignant progression and patient survival, the mechanisms for SPARC function in tumorigenesis and metastasis remain elusive. The activity of SPARC is context- and cell-type-dependent, which is highlighted by the fact that SPARC has shown seemingly contradictory effects on tumor progression in both clinical correlative studies and in animal models. The capacity of SPARC to dictate tumorigenic phenotype has been attributed to its effects on the bioavailability and signaling of integrins and growth factors/chemokines. These molecular pathways contribute to many physiological events affecting malignant progression, including extracellular matrix remodeling, angiogenesis, immune modulation and metastasis. Given that SPARC is credited with such varied activities, this review presents a comprehensive account of the divergent effects of SPARC in human cancers and mouse models, as well as a description of the potential mechanisms by which SPARC mediates these effects. We aim to provide insight into how a matricellular protein such as SPARC might generate paradoxical, yet relevant, tumor outcomes in order to unify an apparently incongruent collection of scientific literature.
Starting Page 255
Ending Page 273
Page Count 19
File Format PDF
ISSN 18739601
Journal Journal of Cell Communication and Signaling
Volume Number 3
Issue Number 3-4
e-ISSN 1873961X
Language English
Publisher Springer Netherlands
Publisher Date 2009-10-07
Publisher Place Dordrecht
Access Restriction Subscribed
Subject Keyword Angiogenesis Extracellular matrix Matricellular protein Metastasis Microenvironment Osteonectin SPARC Tumor Biomedicine general Cell Biology
Content Type Text
Resource Type Article
Subject Cell Biology Biochemistry Molecular Biology
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