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Journal of Genetics : Volume 77

Journal of Genetics : Volume 76

Adaptive mutation inEscherichia coli strain FC40

Content Provider	Springer Nature Link
Author	Foster, Patricia L. Rosche, William A.
Copyright Year	1999
Abstract	Mutations can arise in static populations of cells that are subjected to nonlethal selective pressure, a phenomenon that has been called ‘adaptive mutation’. This phenomenon has been extensively studied in FC40, a strain ofEscherichia coli that cannot metabolize lactose (Lac$^{−}$) but that reverts to lactose utilization (Lac$^{+}$) when lactose is its sole energy and carbon source. The adaptive Lac$^{+}$ mutations arise by two mutational processes: a recombination-dependent process that is highly active on the episome carrying the Lac$^{−}$ allele, and an unknown process that affects the whole genome. Most of the Lac$^{+}$ mutations are due to the first process, which also produces nonselected mutations on the F′ episome. However, about 10% of the Lac$^{+}$ mutations arise in a subpopulation of cells that experience a period of transient hypermutation. Although minor contributors to any one type of mutation, the hypermutators account for nearly all cases of multiple mutations. The evolutionary implications of these results are: (i) DNA synthesis associated with recombination may be an important source of spontaneous mutation, particularly in cells that are not actively growing; (ii) the efficient mutational mechanism that occurs on the episome could result in the horizontal transfer of new alleles among species that carry and exchange conjugal plasmids; and (iii) a subpopulation of transient hypermutators could be a source of multiple mutations that would allow for rapid adaptive evolution under adverse conditions.
Starting Page	7
Ending Page	11
Page Count	5
File Format	PDF
ISSN	00221333
Journal	Journal of Genetics
Volume Number	78
Issue Number	1
Language	English
Publisher	Springer India
Publisher Date	1999-01-01
Publisher Institution	Indian Academy of Sciences
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	spontaneous mutation directed mutation stationary-phase mutation starvation-induced mutation recombination DNA replication Life Sciences Microbial Genetics and Genomics Plant Genetics & Genomics Animal Genetics and Genomics Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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