NDLI: Comparative analysis of gene expression profiles of OPN signalling pathway in four kinds of liver diseases

Content Provider	Springer Nature Link
Author	WANG, GAIPING CHEN, SHASHA ZHAO, CONGCONG LI, XIAOFANG ZHAO, WEIMING YANG, JING CHANG, CUIFANG XU, CUNSHUAN
Copyright Year	2016
Abstract	To explore the relevance of OPN signalling pathway to the occurrence and development of nonalcoholic fatty liver disease (NAFLD), liver cirrhosis (LC), hepatic cancer (HC) and acute hepatic failure (AHF) at transcriptional level, Rat Genome 230 2.0 Array was used to detect expression profiles of OPN signalling pathway-related genes in four kinds of liver diseases. The results showed that 23, 33, 59 and 74 genes were significantly changed in the above four kinds of liver diseases, respectively. H-clustering analysis showed that the expression profiles of OPN signalling-related genes were notably different in four kinds of liver diseases. Subsequently, a total of above-mentioned 147 genes were categorized into four clusters by k-means according to the similarity of gene expression, and expression analysis systematic explorer (EASE) functional enrichment analysis revealed that OPN signalling pathway-related genes were involved in cell adhesion and migration, cell proliferation, apoptosis, stress and inflammatory reaction, etc. Finally, ingenuity pathway analysis (IPA) software was used to predict the functions of OPN signalling-related genes, and the results indicated that the activities of ROS production, cell adhesion and migration, cell proliferation were remarkably increased, while that of apoptosis, stress and inflammatory reaction were reduced in four kinds of liver diseases. In summary, the above physiological activities changed more obviously in LC, HC and AHF than in NAFLD.
Starting Page	741
Ending Page	750
Page Count	10
File Format	PDF
ISSN	00221333
Journal	Journal of Genetics
Volume Number	95
Issue Number	3
e-ISSN	09737731
Language	English
Publisher	Springer India
Publisher Date	2016-08-03
Publisher Institution	Indian Academy of Sciences
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	osteopontin signalling pathway nonalcoholic fatty liver disease liver cirrhosis hepatic cancer acute hepatic failure. Life Sciences Microbial Genetics and Genomics Plant Genetics & Genomics Animal Genetics and Genomics Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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