NDLI: Genetic epidemiology of coronary artery disease: an Asian Indian perspective

Content Provider	Springer Nature Link
Author	JAYASHREE, SHANKER ARINDAM, MAITRA VIJAY, KAKKAR V.
Copyright Year	2015
Abstract	Coronary artery disease (CAD) has emerged as a major cause of morbidity and mortality worldwide. Recent findings on the role of genetic factors in the aetiopathology of CAD have implicated novel genes and variants in addition to those involved in lipid and lipoprotein metabolism. However, our present knowledge is limited due to lack of clarity on their exact identity and the quantum of impact on disease susceptibility, and incident risk. It is a matter of great interest to understand the role of genetic factors in ethnic populations that have a strong underlying predisposition to CAD such as the South Asian populations, particularly among Asian Indians living in India and abroad. Although, a number of isolated studies do implicate certain gene polymorphisms towards enhanced disease susceptibility, the available data remains scanty and inconclusive as they have not been validated in large, prospective cohorts. The present review aims to consolidate the available literature on the genetics of CAD in Asian Indians and seeks to provide insights on the concerns that need to be addressed in future studies to generate information having clinical value.
Starting Page	539
Ending Page	549
Page Count	11
File Format	PDF
ISSN	00221333
Journal	Journal of Genetics
Volume Number	94
Issue Number	3
e-ISSN	09737731
Language	English
Publisher	Springer India
Publisher Date	2015-09-04
Publisher Institution	Indian Academy of Sciences
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	genes coronary artery disease genetic epidemiology single-nucleotide polymorphism Asian Indians Life Sciences Microbial Genetics and Genomics Plant Genetics & Genomics Animal Genetics and Genomics Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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