NDLI: HIV-1 Nef control of cell signalling molecules: Multiple strategies to promote virus replication

Content Provider	Springer Nature Link
Author	Greenway, Alison L. Holloway, Gavan McPhee, Dale A. Ellis, Phoebe Cornall, Alyssa Lidman, Michael
Copyright Year	2003
Abstract	HIV-1 has at its disposal numerous proteins encoded by its genome which provide the required arsenal to establish and maintain infection in its host for a considerable number of years. One of the most important and enigmatic of these proteins is Nef. The Nef protein of HIV-1 plays a fundamental role in the virus life cycle. This small protein of approximately 27 kDa is required for maximal virus replication and disease progression. The mechanisms by which it is able to act as a positive factor during virus replication is an area of intense research and although some controversy surrounds Nef much has been gauged as to how it functions. Its ability to modulate the expression of key cellular receptors important for cell activation and control signal transduction elements and events by interacting with numerous cellular kinases and signalling molecules, including members of the Src family kinases, leading to an effect on host cell function is likely to explain at least in part its role during infection and represents a finely tuned mechanism where this protein assists HIV-1 to control its host.
Starting Page	323
Ending Page	335
Page Count	13
File Format	PDF
ISSN	02505991
Journal	Journal of Biosciences
Volume Number	28
Issue Number	3
e-ISSN	09737138
Language	English
Publisher	Springer India
Publisher Date	2003-01-01
Publisher Institution	Indian Academy of Sciences
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HIV-1 Nef pathogenesis signal transduction Life Sciences Biomedicine general Zoology Plant Sciences Microbiology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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