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Acknowledgements

Journal of Biosciences : Volume 28, Issue 5, September 2003

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Journal of Biosciences : Volume 28, Issue 3, April 2003

Journal of Biosciences : Volume 28, Issue 2, March 2003

Journal of Biosciences : Volume 28, Issue 1, February 2003

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Curcumin-induced inhibition of cellular reactive oxygen species generation: Novel therapeutic implications

Content Provider	Springer Nature Link
Author	Balasubramanyam, M. Koteswari, A. Adaikala Kumar, R. Sampath Monickaraj, S. Finny Maheswari, J. Uma Mohan, V.
Copyright Year	2003
Abstract	There is evidence for increased levels of circulating reactive oxygen species (ROS) in diabetics, as indirectly inferred by the findings of increased lipid peroxidation and decreased antioxidant status. Direct measurements of intracellular generation of ROS using fluorescent dyes also demonstrate an association of oxidative stress with diabetes. Although phenolic compounds attenuate oxidative stress-related tissue damage, there are concerns over toxicity of synthetic phenolic antioxidants and this has considerably stimulated interest in investigating the role of natural phenolics in medicinal applications. Curcumin (the primary active principle in turmeric,Curcuma longa Linn.) has been claimed to represent a potential antioxidant and antiinflammatory agent with phytonutrient and bioprotective properties. However there are lack of molecular studies to demonstrate its cellular action and potential molecular targets. In this study the antioxidant effect of curcumin as a function of changes in cellular ROS generation was tested. Our results clearly demonstrate that curcumin abolished both phorbol-12 myristate-13 acetate (PMA) and thapsigargin-induced ROS generation in cells from control and diabetic subjects. The pattern of these ROS inhibitory effects as a function of dose-dependency suggests that curcumin mechanistically interferes with protein kinase C (PKC) and calcium regulation. Simultaneous measurements of ROS and Ca$^{2+}$ influx suggest that a rise in cytosolic Ca$^{2+}$ may be a trigger for increased ROS generation. We suggest that the antioxidant and antiangeogenic actions of curcumin, as a mechanism of inhibition of Ca$^{2+}$ entry and PKC activity, should be further exploited to develop suitable and novel drugs for the treatment of diabetic retinopathy and other diabetic complications.
Starting Page	715
Ending Page	721
Page Count	7
File Format	PDF
ISSN	02505991
Journal	Journal of Biosciences
Volume Number	28
Issue Number	6
e-ISSN	09737138
Language	English
Publisher	Springer India
Publisher Date	2003-01-01
Publisher Institution	Indian Academy of Sciences
Publisher Place	New Delhi
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Curcumin diabetes oxidative stress reactive oxygen species Life Sciences Biomedicine general Zoology Plant Sciences Microbiology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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